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Tripterygium abstract Obesity is a major health risk, and there is still a lack of effective medication treatment. An effective anti obesity agent, Triptolide, has been found in the roots of Tripterygium wilfordii. However, an effective synthesis method is needed to better explore its biological utility. Here, we elucidate the 11 missing steps in the...

terpenoid Summary Terpenoid are key components of human medicines and are the largest family of natural products. Fungi are important sources of terpenoids, but many of the corresponding biosynthetic gene clusters (BGCs) are silent under laboratory conditions. Strategies such as homologous activation and heterologous expression often used to activate a single cluster and inefficient. Therefore,...

Systems engineering of Escherichia coli for highlevel shikimic acid Research background shikimic acid is a common precursor of drugs and industrial products, including the anti influenza drug Tamiflu (oseltamivir phosphate), aromatic compounds, and chiral chemicals. So far, different host strains including Corynebacterium glutamicum, yeast, and Escherichia coli have engineered to increase shikimic acid production. Among...

This study proves that FrzK is a self-resistant enzyme. Through sequence analysis, homology modeling, crystal structure analysis and point mutation, a series of mutants related to catalytic activity and sensitivity to regulatory inhibitors obtained, indicating that FrzK may pass through Change the conformation of the active site to maintain its PPAT enzyme activity and promote...

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