The role of glutathione in broiler feed


Role of glutathione in chicken feed

Glutathione is an important biomolecule and the most abundant non-protein mercaptan peptide in cells. It exists mainly in eukaryotic cells in reduced form.

It widely distributed in the cell, about 90% located in the cytoplasm, the rest distributed in the mitochondria,

nucleus and endoplasmic reticulum and other suborganelles, and a small amount of extracellular space.

Physiological function of glutathione

  • Antioxidant: GSH is able to scavenge free radicals and protect cells from oxidative damage.
  • Immunomodulation: It plays an important role in the immune response of animals and helps maintain the normal function of the immune system.
  • Detoxification: Glutathione involved in the detoxification process, helping to remove harmful substances from the body.
  • Nutritional role: During nutrient restriction, GSH can used as a source of nitrogen and sulfur, which plays an important role in animal growth and development.

Homeostasis of glutathione

The homeostasis level of intracellular GSH depends on its synthesis, hydrolysis, cycling, and the balance between the reducing and oxidizing states.

The ratio between the oxidized form (GSSG) and the reduced form (GSH) of glutathione is an important indicator of cellular oxidative stress.

Benefits of adding glutathione to broiler feed

  • Improve antioxidant capacity: Reduce oxidative stress.
  • Boost immunity: Improve resistance to disease.
  • Help eliminate toxins from the body: Maintain health.
  • Support growth and development: as a supplementary source of nitrogen and sulfur in the event of nutrient deficiencies.

Synergistic effect

The combination of glutathione with other additives (e.g. vitamins, minerals, etc.) may have a synergistic effect to further enhance the health and production performance of broilers.

Matters needing attention

Moderate addition: Moderate addition can maximize its benefits, but too high a dose may be unhelpful or even harmful.

Stability considerations: The stability of GSH during feed processing and storage needs to considered to ensure its biological activity.


Glutathione plays an important role in broiler feed and can significantly improve the health and production performance of broilers by boosting antioxidant capacity,

boosting immunity, aiding detoxification, and supporting growth and development.

Reasonable addition of GSH, considering its stability, can maximize its effect in feed.