Is NMN safe for human health? Let me tell you NMN is really safe and effective!
In the current era of severe aging, age-related diseases are gradually increasing. You will find that almost everyone around the elderly has one or more age-related diseases:
For example, hypertension, atherosclerosis, diabetes, hyperuricemia, hyperlipidemia, and senile dementia (Alzheimer’s disease) are all caused by aging, that is, cell damage and aging.
Among various functional products designed to address aging issues, NMN is the most recognized and highly regarded component.
Is NMN safe and can it have a positive impact on human health? A recent review on clinical trials of Nicotinamide Mononucleotide summarizes research results from China, the United States, and Japan, published in the journal Advances in Nutrition.
As of the publication date of this review article, 10 clinical trials of NMN have published, 13 completed but unpublished trials, and 11 ongoing trials.
The human body research of NMN has never stopped, and more and more data results have found that Nicotinamide Mononucleotide has anti-aging effects and is very safe, suitable for long-term use!
Five typical NMN security studies
1. Japan/Clinical trial registration: UMIN000021309
This experiment included 10 healthy males aged 40-60, who orally administered 100mg, 250mg, or 500mg respectively. After continuous monitoring for 5 hours, it was found that serum creatinine, chloride, and glucose levels were within the normal range.
This experiment included 32 overweight or obese adults aged 55-80 years old, who orally administered 1000mg NMN once or twice a day for 14 days. It ultimately proven that Nicotinamide Mononucleotide was safe and effective.
3. US/Clinical trial registration: NCT03151239
In this trial, 25 postmenopausal and pre diabetes women aged 55~75 years enrolled, taking 250 mg orally every day for 10 weeks; There NMN metabolites in skeletal muscle, indicating that Nicotinamide Mononucleotide can improve the insulin sensitivity of muscle, and insulin signal transmission enhanced, which helpful for the rehabilitation of diabetes.
4. China/Clinical trial registration number: NCT04228640
This experiment included 8 males aged 45-60 years old,
taking 300mg daily for 1-3 months without significant adverse reactions, proving the safety of NMN.
5. Japan/Clinical trial registration number: jRCTs041200034
This experiment included 31 healthy individuals aged 20 to 65,
taking 1250mg orally daily for 4 weeks, and the results showed safety.
Overall, existing human clinical trials have shown that oral NMN is safe and has demonstrated a certain role of Nicotinamide Mononucleotide in anti-aging.
On the basis of ensuring the intake of scientifically high content β-Nicotinamide Mononucleotide, NMN supplemented with additional ginsenosides. Compared to a single Nicotinamide Mononucleotide, the strong combination of the two has a more significant effect.
After using rare ginsenosides in combination with NMN, the effect directly increased by more than 4 times! By regulating the nicotinamide phosphoribosyltransferase (NAMPT), the absorption and utilization efficiency of Nicotinamide Mononucleotide has greatly improved!