Connection between NMN and NAD+
NMN, short for nicotinamide mononucleotide, is a naturally occurring substance in the body and an important intermediate for the synthesis of NAD+ in the human body.
NAD+ is an important intracellular coenzyme, also known as coenzyme I, full name of nicotinamide adenine dinucleotide, which is involved in thousands of physiological activities in every cell.
NAD+ plays an important role in a variety of cellular metabolic reactions and is an important support for cell vitality.
It is involved in the regulation of many biological processes within cells, including energy metabolism, DNA repair, and apoptosis.
As the most important precursor molecule of NAD+, NMN is the most direct precursor of NAD+ in human body through the role of intracellular metabolic enzymes, and its function is reflected by NAD+.
The decline in NAD+ during aging is believed to be a major cause of disease and disability, such as hearing and vision loss, cognitive and motor dysfunction, immune deficiencies, arthritis due to dysregulated autoimmune inflammatory responses, metabolic disorders, and cardiovascular disease.
Supplementation of NMN increases the content of NAD+ in the body, thereby delaying, improving, and preventing a variety of age-related phenotypes, or age-induced metabolic disorders, diseases of aging, etc.
Manifestations and causes of brain aging
1. Signs of brain aging
With age, the aging of the brain mainly has the following aspects:
- Memory loss: The function of the hippocampus in the brain gradually declines, making it difficult for individuals to remember new things, always forgetting things and forgetting things.
- Decreased thinking ability: The function of areas such as the prefrontal cortex and frontoparietal association cortex is reduced, which hinders people’s thinking ability and judgment ability.
- Language barriers: affect language understanding and expression, manifested as forgetting common words, not answering, and often not making sense.
- Mood and personality changes: affect people’s emotions and personality characteristics, emotions are easy to fluctuate, become withdrawn, easy to get excited, etc., the ability to control emotions declines, and apathy to things that were previously interested in.
- Decreased spatial orientation: The function of the brain region that controls spatial orientation declines, resulting in the perception of distance and direction may be wrong, and it is easy to get lost.
- Cognitive decline: The ability to grasp the real world and solve specific problems becomes worse. There is an increased risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
2. Causes of brain aging
The brain begins to age at the age of 20 for the following reasons:
(1) Mitochondrial depletion:
The loss of mitochondria in cells leads to less energy in the brain.
As we age, the size of the brain gradually decreases, the number of neurons decreases, white matter may become more sparse, and amyloid deposits may increase.
(2) NAD+ levels drop:
As people age, NAD+ levels in the body decline, accelerating brain aging.
Specifically, the rate of total daily energy consumption in humans decreases significantly after middle age, which associated with mitochondrial dysfunction.
In the aging process of the brain, the mitochondria, the “power plant”, has a problem, the power gradually decreases, and the respiration weakened
(3) Bad life factors:
Some bad life factors will also accelerate brain aging, such as smoking, irregular rest, overeating, air pollution, toxic and harmful substances.
The effect of NMN on the brain
1. Protect the brain’s microvessels
A 2019 study by the University of Oklahoma in the United States showed that intraperitoneal injection of NMN had a significant protective effect on cerebral microvessels of aging mice.
NMN alleviates oxidative stress of cerebral microvascular endothelium, improves endothelial function and rescues neurovascular coupling in the cortex of aging mice.
2. Save neurovascular function
A 2020 University of Oklahoma study showed that NMN can restore NAD+ levels and activate Sirt1 in aging mouse cells, thereby saving neurovascular function, increasing cerebral blood flow, and altering cognitive ability.
Neurovascular dysfunction caused by aging considered to a key factor in the pathogenesis of vascular cognitive impairment and neurodegenerative diseases.
3. Prevention of memory dysfunction caused by chemotherapy
In 2021, Mayo Clinic published a paper exploring the protective effect of NMN in preventing chemotherapy-induced memory dysfunction.
NMN found to have a neuroprotective effect against cisplatin induced recognition memory deficits.
4. Multifaceted prevention of nervous system aging
In 2022, the results of the research team of the School of Medicine of Zhejiang University showed that after supplementing NMN, the expression of SIRT2 activated and the regeneration ability of myelin restored, which has great potential in preventing the aging of the nervous system.
Mechanism of NMN protecting neural health
1. Promotes nerve cell growth and repair
The study found that after NMN supplementation given to mice, the density of neurons in the cerebral cortex increased significantly, while the damaged neurons also repaired.
This suggests that NMN plays an important role in maintaining the health of nerve cells.
2. antioxidant
Free radical is one of the important factors that cause nerve cell damage.
NMN can remove free radicals in the body, thereby reducing the damage of oxidative stress to nerve cells.
3. Modulates neuroinflammatory responses
NMN can reduce the level of inflammatory factors and reduce nerve damage.
With age or under the influence of adverse factors, neuroinflammatory responses may increase, causing damage to nerve cells.
The emergence of NMN can effectively reduce the level of inflammatory factors, relieve neuroinflammatory response, and protect nerve cells from further damage.
4. Regulates neurotransmitter synthesis
Supplementing with NMN can increase levels of several neurotransmitters in the brain, such as dopamine, glutamate, and GABA
NMN can regulate the synthesis of neurotransmitters to ensure the smooth transmission of information in the brain and maintain the normal function of the brain.
Four reasons to choose GSHWORLD NMN
- High absorption and utilization rate, realizing the leap from single component to composite component, improving the conversion efficiency of NAD+.
- Comprehensive and high energy efficiency, synergistic by a variety of nutrients, acting on eight systems of the human body.
- Ingenuity quality is higher than similar, with strict production specifications, safety, purity requirements and regulatory testing standards.
- Scientific research laboratory grade raw materials, prepared by cutting-edge technology, three generations of enteric-soluble slow-release technology, fully slow-release absorption.
