What is S-Adenosyl-L-methionine disulfate tosylate?
S-Adenosyl-L-methionine disulfate tosylate is an important physiologically active substance, which can improve mood, relieve bone and joint pain and protect liver, etc. At present, it is mainly used in the field of health products.
S-Adenosyl-L-methionine disulfate tosylate(SAMe), also known as adenosyl-methionine p-toluenesulfonate. Its active substance adenosylmethionine can participate in more than 40 biochemical reactions, and is the active precursor of sulfur compounds such as glutathione, cysteine, taurine and coenzyme A.
- 【 Product name】 S-Adenosyl-L-methionine disulfate tosylate
- 【 Appearance】 White crystalline powder
- 【 CAS 】 97540-22-2
- 【 Molecular weight 】 766.79
- 【 Molecular formula】 C15H22N6O5S·2(H2SO4)·C7H8SO3
Function and application
1. Regulate mood, relieve depression
Adenosylmethionine has been used to improve mood use in Europe since the 1980s. It can effectively regulate mood and improve symptoms of depression and psychosis with fewer side effects.
A review of clinical studies by the FDA’s Agency for Healthcare Research and Quality (AHRQ) concluded that adenosyl methionine is similar to prescription antidepressants in the treatment of depression.
Studies have shown that, when combined with standard antidepressants, including MAO inhibitors, adenosylmethionine can accelerate and improve treatment response (Alpert et al., 2004; Berlanga et al., 1992; Torta et al., 1988).
Mechanism: The methylation function of adenosylmethionine can promote the metabolism of dopamine in the brain and serotonin in the blood, and the methylation of phospholipid helps to enhance the function of the receptor, enhance the density of the receptor and improve the coupling effect of the receptor, which helps to promote the production of neurotransmitters, thus effectively improving the symptoms of depression.
2. Improve joint pain
People with arthritis and fibromyalgia often become depressed. In Europe, adenosylmethionine has been shown to improve osteojoint symptoms and the pain and discomfort of fibromyalgia.
A randomized controlled trial in Germany (over 20,000 patients in total) found that SAMe was as effective as NSaids in reducing bone and joint pain (Bradley et al. 1994).
S-Adenosyl-L-methionine disulfate tosylate shows benefits in improving joint pain:
- 1) Can effectively reduce the pain of arthritis patients;
- 2) Improve joint motion and function, reduce joint stiffness;
- 3) Adenosylmethionine is better tolerated than non-steroidal anti-inflammatory drugs.
- Mechanism: Adenosine helps to promote the formation and repair of cartilage tissue, reducing joint pain, swelling, and stiffness.
3. Protect your pet’s liver
Liver injury has become a major threat to the health of dogs and cats. The following conditions may cause liver damage to pets:
- 1) Pets suffer from diabetes, hyperadrenocortical function, thyroid dysfunction and heart disease;
- 2) Giving pets poor quality dog food, abusing drugs, using poor quality pesticides or excessive disinfectants;
- 3) Bacterial, parasitic, and viral infections can cause liver damage in dogs and cats.
Adenosylmethionine can also applied to pets, not only to strengthen the animal’s liver detoxification function, but also to improve the pet’s cognition, relieve their negative emotions, and create a healthier and happier living environment for the pet.
4. Applications in other fields
S-Adenosyl-L-methionine disulfate tosylate used as a drug in some countries. It can not only used to improve mood and relieve bone and joint pain.
With the deepening of clinical research, It may also have the potential to improve Parkinson’s disease, Alzheimer’s disease, migraine, epilepsy and insulin.
GSHWORLD product features
1. Raw material quality assurance
As a quality raw material supplier of S-Adenosyl-L-methionine Disulfate Tosylate, GSH Bio-Tech products have the following characteristics:
1) Production by microbial fermentation process.
The strain is GRAS safe yeast, the raw material is natural, safe and reliable;
2) Strict internal control standards.
The content of S-Adenosyl-L-methionine Disulfate Tosylate is more than 99%, the content of adenosyl-methionine is high, the control of isomers is low, the impurity is less, and the quality is guaranteed.
3) Product upgrade.
GSH Bio-Tech upgrades the existing products, adopts advanced granulation process, mixes raw materials with a certain proportion of auxiliary materials, adjusts the bulk density and improves its solubility, and launches granulation p-methionine products.
Granulation grade has the following characteristics for methionine products:
- Good liquidity
- Increase powder volume, easy to store and transport
- Controllable dissolution rate
- Not easily caked
2. Multiple authentication system
S-Adenosyl-L-methionine Disulfate Tosylate produced by GSH Bio-Tech is mainly used as raw material for health care products.
At present, it has obtained foreign KOSHER food certification, HALAL food certification, FSMA food safety management system certification, international HACCP food safety certification and other authoritative certifications.
3. Global partner
GSH Bio-Tech has reached cooperation with many well-known manufacturers around the world, and the S-Adenosyl-L-methionine Disulfate Tosylate raw materials produced exported to North America, Europe, Russia, India and other countries and regions.
